Endocrine Abstracts

For a long time it has been suggested that glucocorticoids (GC) mediate their effects solely on the genomic level. A number of studies reported an existence of rapid GC effects independent on gene expression. These effects may play an important role in stress response or during acute GC therapy. As far as we know, rapid inhibitory GC effects on glucose-induced secretion of insulin have been reported only in animals (1). The aim of our study was to evaluate effects of GC on ear...

Context: The interpretation of low-dose ACTH test during endogenous and exogenous hypercortisolemia induced by stress and glucocorticoid therapy in critically ill patients with possible relative adrenal insufficiency.Objective: The hypothesized inhibitory effects of hypercortisolemia on adrenal responsiveness in humans were tested using two model situations in low-dose ACTH testing.Subjects and methods: Nine young healthy women und...